In patients with Crohn’s disease a multicenter prospective study found that anti-TNF therapy failed to achieve remission at 3 years in about two-thirds of cases, and that high drug concentrations early in treatment are linked to greater probability of sustained remission. This suggests that getting biologic therapy right in induction is probably the most important part of treating Crohn’s disease with anti-TNFs.
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Higher Early Anti-TNF Levels May Be Crucial to Treatment Success