Painful sweeping in wrists and feet?

Colitis since 2006. Developed antibody to Humira, Stelara didn’t work- and after a terrible flare in Spring- began Enyvio. Off all steroids and have been mostly in remission for 4 months. Started to flare last week, and went back on Mesalamine enemas at night to get me through to my next infusion. I’ve taken Mesalamine many times, but after 3 day/ doses- I woke up with swelling and pain in my wrists and feet. It hurts to walk. More the right side than the left. Has anyone…