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Inflammation and pressure-sensing leads to ‘feed-forward’ loop in osteoarthritis

Inflammation and pressure-sensing leads to ‘feed-forward’ loop in osteoarthritis

An unfortunate biological ‘feed-forward’ loop drives cartilage cells in an arthritic joint to actually contribute to progression of the disease, say researchers. Excessive loading under inflammatory conditions can create a situation that can lead to progressive cartilage degeneration.

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Michael Jannicelli

Michael Jannicelli - "A PROVEN BUSINESS FIRESTARTER & BRANDING GENIUS" a true natural born Trendsetter. • Created over 100 products under 3 brands, sold in 30+ countries worldwide and influencing youth across the globe. • Featured in Forbes magazine +over 100 print publications, television talk shows, major motion pictures and national radio stations. • Co-founder and VP of Bliss beverage USA and President/co-founder of Socko International - fastest growing privately held beverage company in US (Forbes) with Hogan Energy & Raw Energy WWE. • Co-founder of Throwdown Industries (2003) - leading brand in multibillion dollar Impact/Action Sports Market (products designed for superior MN • Diagnosed with auto-immune diseases aged 13; using his experience to help others and promote a positive message while developing edgy products to benefit people with chronic illness.