Appendicitis
Nature Reviews Disease Primers, Published online: 13 November 2025; doi:10.1038/s41572-025-00659-6
Inflammation of the appendix, acute appendicitis, is one of the most common reasons for acute abdominal pain in children and adults and surgical emergency visits worldwide. In this Primer, Salminen and colleagues review the epidemiology, pathophysiology, diagnosis and management of appendicitis, and discuss future research areas.













