VEXAS syndrome

Posted by Michael Jannicelli | Apr 16, 2026 | Uncategorized | 0 |

Nature Reviews Disease Primers, Published online: 16 April 2026; doi:10.1038/s41572-026-00695-w

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is an autoinflammatory disease caused by somatic mutations in UBA1. In this Primer, Beck and colleagues discuss the epidemiology and mechanisms of VEXAS syndrome, summarize its diagnosis and management, and discuss the quality of life of patients as well as outstanding research questions.

About The Author

Michael Jannicelli

Michael Jannicelli - "A PROVEN BUSINESS FIRESTARTER & BRANDING GENIUS" a true natural born Trendsetter. • Created over 100 products under 3 brands, sold in 30+ countries worldwide and influencing youth across the globe. • Featured in Forbes magazine +over 100 print publications, television talk shows, major motion pictures and national radio stations. • Co-founder and VP of Bliss beverage USA and President/co-founder of Socko International - fastest growing privately held beverage company in US (Forbes) with Hogan Energy & Raw Energy WWE. • Co-founder of Throwdown Industries (2003) - leading brand in multibillion dollar Impact/Action Sports Market (products designed for superior MN • Diagnosed with auto-immune diseases aged 13; using his experience to help others and promote a positive message while developing edgy products to benefit people with chronic illness.