Environmental factors, not genetics, confer the highest risk of developing CD in multiplex families.
Healthy first-degree relatives from multiplex families versus simplex families have a higher subclinical intestinal inflammation, a distinct fecal microbial signature, and harbor a higher risk of developing Crohn’s disease
University of Toronto, Ontario, Canada
2024 Sep
Background & aims: Unaffected first-degree relatives (FDRs) from families with two or more affected FDRs with Crohn’s disease (CD, multiplex families) have a high risk of developing CD…
Environmental factors, not genetics, confer the highest risk of developing CD in multiplex families.
