Genetic variants and crohn’s disease. Some perspective.
Genetic variants associated with crohn’s disease are incredibly common in the human populace.
The most common genetic variant that is most closely associated with Crohn’s disease is NOD2, one of the receptors involved in recognition of intracellular pathogens, including sensing of mycobateria. Intracellular pathogens are pathogens that invade cells of the host. So your common foodborne pathogens like E Coli and Salmonella, but also mycobacteria like MAP, TB and Leprae for example…
