Iron overload: The hidden culprit behind early Alzheimer’s in Down syndrome

USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer’s in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with both conditions had twice the iron levels and far more oxidative damage than others. The culprit appears to be ferroptosis, an iron-triggered cell death mechanism, which is especially damaging in sensitive brain regions.