Premature ovarian insufficiency
Nature Reviews Disease Primers, Published online: 12 September 2024; doi:10.1038/s41572-024-00547-5
Premature ovarian insufficiency (POI) is defined as the loss of normal ovarian activity before the age of 40 years, and is a cause of infertility and endocrine dysfunction in women. This Primer outlines the epidemiology and pathophysiology of POI, including associated gene variants, and discusses diagnosis, management and quality of life for women with POI.