Study gives insight into cause of severe inflammatory bowel disease
![Study gives insight into cause of severe inflammatory bowel disease](https://crohnsfighters.com/wp-content/uploads/2023/02/scidaily-logo-rss.png)
Investigators have identified a genetic variant that increases people’s risk of developing perianal Crohn’s disease, the most debilitating manifestation of Crohn’s disease. The variant generates changes to DNA that lead to a loss of protein function, which in turn, alters how the body recognizes and handles bacteria, making it less effective at fighting infections.